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RNA polymerase III-specific general transcription factor IIIC contains a heterodimer resembling TFIIF Rap30/Rap74.

Taylor NM, Baudin F, von Scheven G, Müller CW
Nucleic Acids Res 41 9183-96 (2013)
Cited: 17 times
EuropePMC logo PMID: 23921640

Abstract

Transcription of tRNA-encoding genes by RNA polymerase (Pol) III requires the six-subunit general transcription factor IIIC that uses subcomplexes τA and τB to recognize two gene-internal promoter elements named A- and B-box. The Schizosaccharomyces pombe τA subcomplex comprises subunits Sfc1, Sfc4 and Sfc7. The crystal structure of the Sfc1/Sfc7 heterodimer reveals similar domains and overall domain architecture to the Pol II-specific general transcription factor TFIIF Rap30/Rap74. The N-terminal Sfc1/Sfc7 dimerization module consists of a triple β-barrel similar to the N-terminal TFIIF Rap30/Rap74 dimerization module, whereas the C-terminal Sfc1 DNA-binding domain contains a winged-helix domain most similar to the TFIIF Rap30 C-terminal winged-helix domain. Sfc1 DNA-binding domain recognizes single and double-stranded DNA by an unknown mechanism. Several features observed for A-box recognition by τA resemble the recognition of promoters by bacterial RNA polymerase, where σ factor unfolds double-stranded DNA and stabilizes the non-coding DNA strand in an open conformation. Such a function has also been proposed for TFIIF, suggesting that the observed structural similarity between Sfc1/Sfc7 and TFIIF Rap30/Rap74 might also reflect similar functions.

Articles - 4bji mentioned but not cited (2)

  1. RNA polymerase III-specific general transcription factor IIIC contains a heterodimer resembling TFIIF Rap30/Rap74. Taylor NM, Baudin F, von Scheven G, Müller CW. Nucleic Acids Res. 41 9183-9196 (2013)
  2. Structure of the TFIIIC subcomplex τA provides insights into RNA polymerase III pre-initiation complex formation. Vorländer MK, Jungblut A, Karius K, Baudin F, Grötsch H, Kosinski J, Müller CW. Nat Commun 11 4905 (2020)


Reviews citing this publication (5)

  1. Comparative overview of RNA polymerase II and III transcription cycles, with focus on RNA polymerase III termination and reinitiation. Arimbasseri AG, Rijal K, Maraia RJ. Transcription 5 e27639 (2014)
  2. Zooming in on Transcription Preinitiation. Gupta K, Sari-Ak D, Haffke M, Trowitzsch S, Berger I. J. Mol. Biol. 428 2581-2591 (2016)
  3. RNA polymerase I and III: similar yet unique. Khatter H, Vorländer MK, Müller CW. Curr. Opin. Struct. Biol. 47 88-94 (2017)
  4. Specialization versus conservation: How Pol I and Pol III use the conserved architecture of the pre-initiation complex for specialized transcription. Hoffmann NA, Sadian Y, Tafur L, Kosinski J, Müller CW. Transcription 7 127-132 (2016)
  5. Unveiling the role of GAS41 in cancer progression. Ji K, Li L, Liu H, Shen Y, Jiang J, Zhang M, Teng H, Yan X, Zhang Y, Cai Y, Zhou H. Cancer Cell Int 23 245 (2023)

Articles citing this publication (10)

  1. Architecture of TFIIIC and its role in RNA polymerase III pre-initiation complex assembly. Male G, von Appen A, Glatt S, Taylor NM, Cristovao M, Groetsch H, Beck M, Müller CW. Nat Commun 6 7387 (2015)
  2. Crystal structure of a TAF1-TAF7 complex in human transcription factor IID reveals a promoter binding module. Wang H, Curran EC, Hinds TR, Wang EH, Zheng N. Cell Res. 24 1433-1444 (2014)
  3. Structural and functional insight into TAF1-TAF7, a subcomplex of transcription factor II D. Bhattacharya S, Lou X, Hwang P, Rajashankar KR, Wang X, Gustafsson JÅ, Fletterick RJ, Jacobson RH, Webb P. Proc. Natl. Acad. Sci. U.S.A. 111 9103-9108 (2014)
  4. Structural analysis of human RPC32β-RPC62 complex. Boissier F, Dumay-Odelot H, Teichmann M, Fribourg S. J. Struct. Biol. 192 313-319 (2015)
  5. Structural studies of RFCCtf18 reveal a novel chromatin recruitment role for Dcc1. Wade BO, Liu HW, Samora CP, Uhlmann F, Singleton MR. EMBO Rep. 18 558-568 (2017)
  6. Characterization of Tau95 led to the identification of a four-subunit TFIIIC complex in trypanosomatid parasites. Mondragón-Rosas F, Florencio-Martínez LE, Villa-Delavequia GS, Manning-Cela RG, Carrero JC, Nepomuceno-Mejía T, Martínez-Calvillo S. Appl Microbiol Biotechnol 108 109 (2024)
  7. Conditional depletion of the RNA polymerase I subunit PAF53 reveals that it is essential for mitosis and enables identification of functional domains. McNamar R, Abu-Adas Z, Rothblum K, Knutson BA, Rothblum LI. J Biol Chem 294 19907-19922 (2019)
  8. Nucleotide Loading Modes of Human RNA Polymerase II as Deciphered by Molecular Simulations. Génin NEJ, Weinzierl ROJ. Biomolecules 10 (2020)
  9. RNA polymerase III control elements are required for trans-activation by the murine retroviral long terminal repeat sequences. Hwang YW, Yoo NK, Yang HM, Choi SY. Biochem. Biophys. Res. Commun. 456 110-115 (2015)
  10. Super elongation complex contains a TFIIF-related subcomplex. Knutson BA, Smith ML, Walker-Kopp N, Xu X. Transcription 7 133-140 (2016)


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