› 4bgq

X-ray diffraction
2Å resolution

Crystal structure of the human CDKL5 kinase domain

Released:
DOI: 10.2210/pdb4bgq/pdb
PDB entry 4bgq coloured by chain, front view.
PDB entry 4bgq coloured by chain, side view.
PDB entry 4bgq coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
CDKL Family Kinases Have Evolved Distinct Structural Features and Ciliary Function.
Canning P, Park K, Gonçalves J, Li C, Howard CJ, Sharpe TD, Holt LJ, Pelletier L, Bullock AN, Leroux MR
Cell Rep 22 885-894 (2018)
PMID: 29420175

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-131191 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cyclin-dependent kinase-like 5 Chain: A
Molecule details ›
Chain: A
Length: 304 amino acids
Theoretical weight: 35.23 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: O76039 (Residues: 1-303; Coverage: 32%)
Gene names: CDKL5, STK9
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

4 bound ligands:
Ligand NA 1 x NA
Ligand 38R 1 x 38R
Ligand EDO 2 x EDO
Ligand ACT 2 x ACT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: P212121
Unit cell:
a: 51.942Å b: 65.507Å c: 102.899Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.175 0.174 0.201
Expression system: Spodoptera frugiperda

Quick links

Citations

10 review citations

Cilia Distal Domain: Diversity in Evolutionarily Conserved Structures.
Soares et al. (2019)
9 more

8 mentions without citation

Cyclin-Dependent Kinase-Like 5 Deficiency Disorder: Clinical Review.
Olson et al. (2019)
7 more