X-ray diffraction
1.95Å resolution

Crystal Structure of CDK2 in complex with pan-CDK Inhibitor

Source organism: Homo sapiens
Entry authors: Luecking U, Jautelat R, Krueger M, Brumby T, Lienau P, Schaefer M, Briem H, Schulze J, Hillisch A, Reichel A, Siemeister G

Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Cyclin-dependent kinase 2 Chain: A
Molecule details ›
Chain: A
Length: 298 amino acids
Theoretical weight: 33.98 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
  • Canonical: P24941 (Residues: 1-298; Coverage: 100%)
Gene names: CDK2, CDKN2
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF
Spacegroup: P212121
Unit cell:
a: 53.076Å b: 71.795Å c: 72.196Å
α: 90° β: 90° γ: 90°
R R work R free
0.196 0.193 0.246
Expression system: Spodoptera frugiperda