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Phosphomimetic mutant of LSD1-8a splicing variant in complex with CoREST

X-ray diffraction
3.1Å resolution
PDB entry 4bay coloured by chain, front view.
PDB entry 4bay coloured by chain, side view.
PDB entry 4bay coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: REST corepressor 1 and Lysine-specific histone demethylase 1A
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Multimeric state: hetero dimer
Accessible surface area: 38241.88 Å2
Buried surface area: 6776.73 Å2
Dissociation area: 2,666.14 Å2
Dissociation energy (ΔGdiss): 34.26 kcal/mol
Dissociation entropy (TΔSdiss): 13.94 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-129967

Macromolecules

Lysine-specific histone demethylase 1A
Chain: A
Length: 686 amino acids
Theoretical weight: 76.22 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: O60341 (Residues: 172-369, 370-852; Coverage: 80%)
Gene names: AOF2, KDM1, KDM1A, KIAA0601, LSD1
Pfam:
InterPro:
CATH:
Lysine-specific histone demethylase 1A in PDB entry 4bay, assembly 1, front view.
Lysine-specific histone demethylase 1A in PDB entry 4bay, assembly 1, side view.
Lysine-specific histone demethylase 1A in PDB entry 4bay, assembly 1, top view.
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REST corepressor 1
Chain: B
Length: 133 amino acids
Theoretical weight: 15.32 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q9UKL0 (Residues: 311-443; Coverage: 27%)
Gene names: KIAA0071, RCOR, RCOR1
Pfam:
InterPro:
CATH: Methane Monooxygenase Hydroxylase; Chain G, domain 1
REST corepressor 1 in PDB entry 4bay, assembly 1, front view.
REST corepressor 1 in PDB entry 4bay, assembly 1, side view.
REST corepressor 1 in PDB entry 4bay, assembly 1, top view.
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