EC 1.14.11.n4: Ankyrin-repeat-histidine dioxagenase
Reaction catalysed:
[Ankyrin-repeat domain protein]-L-asparagine + 2-oxoglutarate + O(2) = [ankyrin-repeat domain protein]-(3S)-3-hydroxy-L-asparagine + succinate + CO(2)
Systematic name:
Ankyrin-repeat-L-histidine,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating)
EC 1.14.11.30: Hypoxia-inducible factor-asparagine dioxygenase
Reaction catalysed:
Hypoxia-inducible factor-L-asparagine + 2-oxoglutarate + O(2) = hypoxia-inducible factor-(3S)-3-hydroxy-L-asparagine + succinate + CO(2)
Systematic name:
Hypoxia-inducible factor-L-asparagine, 2-oxoglutarate:oxygen oxidoreductase (4-hydroxylating)
Alternative Name(s):
- HIF hydroxylase
GO terms
Biochemical function:
- ankyrin repeat binding
- peptidyl-aspartic acid 3-dioxygenase activity
- dioxygenase activity
- NF-kappaB binding
- metal ion binding
- protein homodimerization activity
- [protein]-asparagine 3-dioxygenase activity
- peptidyl-histidine dioxygenase activity
- carboxylic acid binding
- oxygen sensor activity
- oxidoreductase activity
- zinc ion binding
- ferrous iron binding
- protein binding
- Notch binding
- transcription corepressor activity