› 4b7c

X-ray diffraction
2.1Å resolution

Crystal structure of hypothetical protein PA1648 from Pseudomonas aeruginosa.

Released:
DOI: 10.2210/pdb4b7c/pdb
PDB 4b7c coloured by chain and viewed from the front.
PDB 4b7c coloured by chain and viewed from the side.
PDB 4b7c coloured by chain and viewed from the top.
Source organism: Pseudomonas aeruginosa PAO1
Entry authors: Alphey MS, McMahon SA, Duthie FG, Naismith JH

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
PKS_ER domain-containing protein Chains: A, B, C, D, E, F, G, H, I, J, K, L
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J, K, L
Length: 336 amino acids
Theoretical weight: 36.33 KDa
Source organism: Pseudomonas aeruginosa PAO1
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9I377 (Residues: 1-334; Coverage: 100%)
Gene name: PA1648
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand MES 5 x MES
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: P212121
Unit cell:
a: 170.93Å b: 177.09Å c: 181.66Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.224 0.223 0.243
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

4 review citations

Using Structure-guided Fragment-Based Drug Discovery to Target Pseudomonas aeruginosa Infections in Cystic Fibrosis.
Arif et al. (2022)
3 more

1 mention without citation

The AEROPATH project targeting Pseudomonas aeruginosa: crystallographic studies for assessment of potential targets in early-stage drug discovery.
Moynie et al. (2013)