› 4b7b

X-ray diffraction
2.5Å resolution

Eg5-3

Released:
DOI: 10.2210/pdb4b7b/pdb
PDB 4b7b coloured by chain and viewed from the front.
PDB 4b7b coloured by chain and viewed from the side.
PDB 4b7b coloured by chain and viewed from the top.
Source organism: Homo sapiens
Entry authors: Talapatra SK, Kozielski F

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Kinesin-like protein KIF11 Chain: A
Molecule details ›
Chain: A
Length: 368 amino acids
Theoretical weight: 41.08 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P52732 (Residues: 1-368; Coverage: 35%)
Gene names: EG5, KIF11, KNSL1, TRIP5
Sequence domains: Kinesin motor domain
Structure domains: Kinesin motor domain

Ligands and Environments

5 bound ligands:
Ligand ADP 1 x ADP
Ligand CD 11 x CD
Ligand CL 10 x CL
Ligand CO 5 x CO
Ligand CA 1 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: P65
Unit cell:
a: 81.5Å b: 81.5Å c: 114.921Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.183 0.179 0.25
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

1 review citation

Recent findings and future directions for interpolar mitotic kinesin inhibitors in cancer therapy.
Myers et al. (2016)
12 other articles