4b12

X-ray diffraction
1.79Å resolution

Plasmodium vivax N-myristoyltransferase with a bound benzofuran inhibitor (compound 23)

Released:

Function and Biology Details

Reaction catalysed:
Tetradecanoyl-CoA + an N-terminal-glycyl-[protein] = CoA + an N-terminal-N-tetradecanoylglycyl-[protein]
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glycylpeptide N-tetradecanoyltransferase Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 385 amino acids
Theoretical weight: 45.08 KDa
Source organism: Plasmodium vivax
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: A5K1A2 (Residues: 27-410; Coverage: 94%)
Gene name: PVX_085815
Structure domains: Aminopeptidase

Ligands and Environments


Cofactor: Ligand NHW 3 x NHW
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I02
Spacegroup: P212121
Unit cell:
a: 57.47Å b: 121.92Å c: 178.25Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.188 0.185 0.239
Expression system: Escherichia coli BL21(DE3)