X-ray diffraction
1.56Å resolution

Plasmodium vivax N-myristoyltransferase with a non-hydrolysable co- factor

Source organism: Plasmodium vivax
Entry authors: Yu Z, Brannigan JA, Moss DK, Brzozowski AM, Wilkinson AJ, Holder AA, Tate EW, Leatherbarrow RJ

Function and Biology Details

Reaction catalysed:
Tetradecanoyl-CoA + an N-terminal-glycyl-[protein] = CoA + an N-terminal-N-tetradecanoylglycyl-[protein]
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Glycylpeptide N-tetradecanoyltransferase Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 385 amino acids
Theoretical weight: 45.08 KDa
Source organism: Plasmodium vivax
Expression system: Escherichia coli BL21(DE3)
  • Canonical: A5K1A2 (Residues: 27-410; Coverage: 94%)
Gene name: PVX_085815
Sequence domains:
Structure domains: Aminopeptidase

Ligands and Environments

Cofactor: Ligand NHW 3 x NHW
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: P212121
Unit cell:
a: 57.37Å b: 119.06Å c: 176.4Å
α: 90° β: 90° γ: 90°
R R work R free
0.191 0.188 0.238
Expression system: Escherichia coli BL21(DE3)