4at4

X-ray diffraction
2.36Å resolution

CRYSTAL STRUCTURE OF TRKB KINASE DOMAIN IN COMPLEX WITH EX429

Released:

Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
BDNF/NT-3 growth factors receptor Chain: A
Molecule details ›
Chain: A
Length: 299 amino acids
Theoretical weight: 34.35 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q16620 (Residues: 527-822; Coverage: 37%)
Gene names: NTRK2, TRKB
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-1
Spacegroup: P21212
Unit cell:
a: 88.08Å b: 95.36Å c: 46.06Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.183 0.179 0.217
Expression system: Spodoptera frugiperda