4apc

X-ray diffraction
2.1Å resolution

Crystal Structure of Human NIMA-related Kinase 1 (NEK1)

Released:

Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine/threonine-protein kinase Nek1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 350 amino acids
Theoretical weight: 39.91 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q96PY6 (Residues: 1-328; Coverage: 26%)
Gene names: KIAA1901, NEK1
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I24
Spacegroup: C2221
Unit cell:
a: 89.91Å b: 92.81Å c: 163.94Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.216 0.215 0.248
Expression system: Escherichia coli BL21(DE3)