EC 2.3.2.24: (E3-independent) E2 ubiquitin-conjugating enzyme
Reaction catalysed:
(1a) S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [(E3-independent) E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-monoubiquitinyl-[(E3-independent) ubiquitin-conjugating enzyme]-L-cysteine
Systematic name:
S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine:L-lysine ubiquitinyl transferase ([E3 ubiquitin transferase]-independent)
Alternative Name(s):
- E2-230K
- E3-independent ubiquitin-conjugating enzyme E2
- UBE2O
EC 2.3.2.23: E2 ubiquitin-conjugating enzyme
Reaction catalysed:
S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine
Systematic name:
S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine:[E2 ubiquitin-conjugating enzyme] ubiquitinyl transferase
Alternative Name(s):
- UBC
- Ubiquitin-carrier-protein E2
- Ubiquitin-conjugating enzyme E2
EC 2.3.2.27: RING-type E3 ubiquitin transferase
Reaction catalysed:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine
Systematic name:
[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine:[acceptor protein]-L-lysine ubiquitin transferase (isopeptide bond-forming; RING-type)
Alternative Name(s):
- RING E3 ligase
- Ubiquitin transferase RING E3
GO terms
Biochemical function:
Biological process:
- negative regulation of TORC1 signaling
- positive regulation of protein polyubiquitination
- protein K48-linked ubiquitination
- proteasome-mediated ubiquitin-dependent protein catabolic process
- positive regulation of protein ubiquitination
- negative regulation of BMP signaling pathway
- protein ubiquitination
- ubiquitin-dependent protein catabolic process
- protein polyubiquitination
- negative regulation of transcription by RNA polymerase II
Cellular component:
Sequence families
Protein families (Pfam)
![The deposited structure of PDB entry 4ap4 contains 2 copies of Pfam domain PF00240 (Ubiquitin family) in Ubiquitin. Showing 1 copy in chain E [auth F].](https://www.ebi.ac.uk/pdbe/static/entry/4ap4_3_F_Pfam_PF00240_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>4ap4</span> contains 2 copies of Pfam domain <span class='highlight'>PF00240 (Ubiquitin family)</span> in <span class='highlight'>Ubiquitin</span>. Showing 1 copy in chain <span class='highlight'>E [auth F]</span>.")
InterPro annotations
Structure domains
CATH domains
3.10.20.90
Class:
Alpha Beta
Architecture:
Roll
Topology:
Ubiquitin-like (UB roll)
Homology:
Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1
Occurring in:
![The deposited structure of PDB entry 4ap4 contains 2 copies of CATH domain 3.10.20.90 (Ubiquitin-like (UB roll)) in Ubiquitin. Showing 1 copy in chain E [auth F].](https://www.ebi.ac.uk/pdbe/static/entry/4ap4_3_F_CATH_3.10.20.90_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>4ap4</span> contains 2 copies of CATH domain <span class='highlight'>3.10.20.90 (Ubiquitin-like (UB roll))</span> in <span class='highlight'>Ubiquitin</span>. Showing 1 copy in chain <span class='highlight'>E [auth F]</span>.")
3.10.110.10
Class:
Alpha Beta
Architecture:
Roll
Topology:
Ubiquitin Conjugating Enzyme
Homology:
Ubiquitin Conjugating Enzyme
Occurring in:
