X-ray diffraction
2.59Å resolution

The mitotic kinesin Eg5 in complex with Mg-ADP and ispinesib

Source organism: Homo sapiens
Primary publication:
The structure of the ternary Eg5-ADP-ispinesib complex.
OpenAccess logo Acta Crystallogr. D Biol. Crystallogr. 68 1311-9 (2012)
PMID: 22993085

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Kinesin-like protein KIF11 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 370 amino acids
Theoretical weight: 41.21 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
  • Canonical: P52732 (Residues: 1-368; Coverage: 35%)
Gene names: EG5, KIF11, KNSL1, TRIP5
Sequence domains: Kinesin motor domain
Structure domains: Kinesin motor domain

Ligands and Environments

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I02
Spacegroup: P21
Unit cell:
a: 64.723Å b: 112.607Å c: 106.913Å
α: 90° β: 90.02° γ: 90°
R R work R free
0.206 0.204 0.252
Expression system: Escherichia coli BL21(DE3)