› › Function and Biology

CRYSTAL STRUCTURE OF THE GRACILARIOPSIS LEMANEIFORMIS ALPHA-1,4- GLUCAN LYASE Covalent Intermediate Complex with 5-fluoro-glucosyl- fluoride

Source organism: Gracilariopsis lemaneiformis
Biochemical function: alpha-glucosidase activity
Biological process: metabolic process
Cellular component: glucosidase II complex

Quick links

EC 4.2.2.13: Exo-(1->4)-alpha-D-glucan lyase

Reaction catalysed:
Linear alpha-glucan = (n-1) 1,5-anhydro-D-fructose + D-glucose
Systematic name:
(1->4)-alpha-D-glucan exo-4-lyase (1,5-anhydro-D-fructose-forming)
Alternative Name(s):
  • Alpha-(1->4)-glucan 1,5-anhydro-D-fructose eliminase
  • Alpha-1,4-glucan 1,5-anhydro-D-fructose eliminase
  • Alpha-1,4-glucan exo-lyase
  • Alpha-1,4-glucan lyase
  • Exo-(1,4)-alpha-D-glucan lyase
  • Exo-alpha-1,4-glucan lyase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF21365
Domain description: Glycosyl hydrolase family 31 C-terminal domain
Occurring in:
  1. Glucosidase II subunit alpha
The deposited structure of PDB entry 4amx contains 4 copies of Pfam domain PF21365 (Glycosyl hydrolase family 31 C-terminal domain) in Alpha-1,4-glucan lyase isozyme 1. Showing 1 copy in chain A.

PF01055
Domain description: Glycosyl hydrolases family 31 TIM-barrel domain
Occurring in:
  1. Glucosidase II subunit alpha
The deposited structure of PDB entry 4amx contains 4 copies of Pfam domain PF01055 (Glycosyl hydrolases family 31 TIM-barrel domain) in Alpha-1,4-glucan lyase isozyme 1. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR013780
Domain description: Glycosyl hydrolase, all-beta
Occurring in:
  1. Glucosidase II subunit alpha
IPR000322
Domain description: Glycoside hydrolase family 31, TIM barrel domain
Occurring in:
  1. Glucosidase II subunit alpha
IPR017853
Domain description: Glycoside hydrolase superfamily
Occurring in:
  1. Glucosidase II subunit alpha
IPR011013
Domain description: Galactose mutarotase-like domain superfamily
Occurring in:
  1. Glucosidase II subunit alpha

Structure domains

CATH CATH domains
2.60.40.1180
Class: Mainly Beta
Architecture: Sandwich
Topology: Immunoglobulin-like
Homology: Golgi alpha-mannosidase II
Occurring in:
  1. Glucosidase II subunit alpha
The deposited structure of PDB entry 4amx contains 8 copies of CATH domain 2.60.40.1180 (Immunoglobulin-like) in Alpha-1,4-glucan lyase isozyme 1. Showing 2 copies in chain A.
2.60.40.1760
Class: Mainly Beta
Architecture: Sandwich
Topology: Immunoglobulin-like
Homology: glycosyl hydrolase (family 31)
Occurring in:
  1. Glucosidase II subunit alpha
The deposited structure of PDB entry 4amx contains 4 copies of CATH domain 2.60.40.1760 (Immunoglobulin-like) in Alpha-1,4-glucan lyase isozyme 1. Showing 1 copy in chain A.

Quick links