Structure analysis

N-Terminal Bromodomain of Human BRD2 With IBET-151

X-ray diffraction
1.6Å resolution
Source organism: Homo sapiens
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

Assemblies

Assembly 1 (preferred)
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Multimeric state: homo dimer
Accessible surface area: 12500 Å2
Buried surface area: 4300 Å2
Dissociation area: 1,000 Å2
Dissociation energy (ΔGdiss): 3 kcal/mol
Dissociation entropy (TΔSdiss): 12 kcal/mol
Interface energy (ΔGint): -11 kcal/mol
Symmetry number: 2

Macromolecules

Chain: A
Length: 154 amino acids
Theoretical weight: 17.91 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P25440 (Residues: 67-200; Coverage: 17%)
  • Best match: P25440-4 (Residues: 1-80)
Gene names: BRD2, KIAA9001, RING3
Pfam: Bromodomain
InterPro:
CATH: Bromodomain-like

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