X-ray diffraction
1.95Å resolution

Crystal structure of Human PS-1 GSH-analog complex

Source organism: Homo sapiens
Entry authors: Sjogren T, Nord J, Ek M, Johansson P, Liu G, Geschwindner S

Function and Biology Details

Reactions catalysed:
(5Z,13E)-(15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate
RX + glutathione = HX + R-S-glutathione
Biochemical function:
Cellular component:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Prostaglandin E synthase Chain: A
Molecule details ›
Chain: A
Length: 152 amino acids
Theoretical weight: 17.12 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
  • Canonical: O14684 (Residues: 1-152; Coverage: 100%)
Gene names: MGST1L1, MPGES1, PGES, PIG12, PTGES
Sequence domains: MAPEG family
Structure domains: Membrane associated eicosanoid/glutathione metabolism-like domain

Ligands and Environments

Cofactor: Ligand 48T 1 x 48T
3 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-2
Spacegroup: R3
Unit cell:
a: 76.623Å b: 76.623Å c: 123.349Å
α: 90° β: 90° γ: 120°
R R work R free
0.163 0.172 0.172
Expression system: Spodoptera frugiperda