› 4aj0

X-ray diffraction
1.7Å resolution

Crystallographic structure of an amyloidogenic variant, 3rCW, of the germinal line lambda 3

Released:
DOI: 10.2210/pdb4aj0/pdb
PDB 4aj0 coloured by chain and viewed from the front.
PDB 4aj0 coloured by chain and viewed from the side.
PDB 4aj0 coloured by chain and viewed from the top.
Source organism: Homo sapiens
Entry authors: Villalba MI, Luna OD, Rudino-Pinera E, Sanchez R, Sanchez-Lopez R, Rojas-Trejo S, Olamendi-Portugal T, Fernandez-Velasco DA, Becerril B

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
GERMINAL LINE LAMBDA 3 3RCW VARIANT Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 107 amino acids
Theoretical weight: 11.29 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
Structure domains: Immunoglobulins

Ligands and Environments

2 bound ligands:
Ligand PG0 2 x PG0
Ligand ACT 1 x ACT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X6A
Spacegroup: P31
Unit cell:
a: 41.807Å b: 41.807Å c: 171.035Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.176 0.174 0.212
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

7 citation in other articles

Epigallocatechin-3-gallate preferentially induces aggregation of amyloidogenic immunoglobulin light chains.
Hora et al. (2017)
6 more

1 mention without citation

Site-directed mutagenesis reveals regions implicated in the stability and fiber formation of human λ3r light chains.
Villalba et al. (2015)