X-ray diffraction
1.96Å resolution

V113I - Angiogenin mutants and amyotrophic lateral sclerosis - a biochemical and biological analysis

Source organism: Homo sapiens
Entry authors: Thiyagarajan N, Ferguson R, Saha S, Pham T, Subramanian V, Acharya KR

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Angiogenin Chain: A
Molecule details ›
Chain: A
Length: 123 amino acids
Theoretical weight: 14.18 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
  • Canonical: P03950 (Residues: 25-147; Coverage: 100%)
Gene names: ANG, RNASE5
Sequence domains: Pancreatic ribonuclease
Structure domains: Ribonuclease A-like domain

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I02
Spacegroup: C2221
Unit cell:
a: 82.269Å b: 118.284Å c: 37.215Å
α: 90° β: 90° γ: 90°
R R work R free
0.198 0.196 0.221
Expression system: Escherichia coli BL21(DE3)