PDBe 4ae7

X-ray diffraction
1.45Å resolution

Crystal structure of human THEM5

Released:

Function and Biology Details

Reaction catalysed:
Palmitoyl-CoA + H(2)O = CoA + palmitate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Acyl-coenzyme A thioesterase THEM5 Chain: A
Molecule details ›
Chain: A
Length: 220 amino acids
Theoretical weight: 24.54 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q8N1Q8 (Residues: 35-247; Coverage: 86%)
Gene names: ACOT15, THEM5
Sequence domains: Thioesterase superfamily
Structure domains: Hotdog Thioesterase

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: C2221
Unit cell:
a: 45.389Å b: 88.634Å c: 105.323Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.142 0.14 0.171
Expression system: Escherichia coli BL21