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Recognition of mono-ADP-ribosylated ARTD10 substrates by ARTD8 macrodomains.

Forst AH, Karlberg T, Herzog N, Thorsell AG, Gross A, Feijs KL, Verheugd P, Kursula P, Nijmeijer B, Kremmer E, Kleine H, Ladurner AG, Schüler H, Lüscher B
Structure 21 462-75 (2013)
Related entries: 3q6z, 3q71, 3v2b, 3vfq, 4abl, 4d86

Cited: 72 times
EuropePMC logo PMID: 23473667

Abstract

ADP-ribosyltransferases (ARTs) catalyze the transfer of ADP-ribose from NAD(+) onto substrates. Some ARTs generate in an iterative process ADP-ribose polymers that serve as adaptors for distinct protein domains. Other ARTs, exemplified by ARTD10, function as mono-ADP-ribosyltransferases, but it has been unclear whether this modification occurs in cells and how it is read. We observed that ARTD10 colocalized with ARTD8 and defined its macrodomains 2 and 3 as readers of mono-ADP-ribosylation both in vitro and in cells. The crystal structures of these two ARTD8 macrodomains and isothermal titration calorimetry confirmed their interaction with ADP-ribose. These macrodomains recognized mono-ADP-ribosylated ARTD10, but not poly-ADP-ribosylated ARTD1. This distinguished them from the macrodomain of macroH2A1.1, which interacted with poly- but not mono-ADP-ribosylated substrates. Moreover, Ran, an ARTD10 substrate, was also read by ARTD8 macrodomains. This identifies readers of mono-ADP-ribosylated proteins, defines their structures, and demonstrates the presence of this modification in cells.

Reviews - 4abk mentioned but not cited (2)

  1. Novel drug targets for personalized precision medicine in relapsed/refractory diffuse large B-cell lymphoma: a comprehensive review. Camicia R, Winkler HC, Hassa PO. Mol Cancer 14 207 (2015)
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Articles - 4abk mentioned but not cited (2)

  1. ADP-ribose and analogues bound to the deMARylating macrodomain from the bat coronavirus HKU4. Hammond RG, Schormann N, McPherson RL, Leung AKL, Deivanayagam CCS, Johnson MA. Proc Natl Acad Sci U S A 118 e2004500118 (2021)
  2. PARP14 is a writer, reader, and eraser of mono-ADP-ribosylation. Torretta A, Chatzicharalampous C, Ebenwaldner C, Schüler H. J Biol Chem 299 105096 (2023)


Reviews citing this publication (23)

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Articles citing this publication (45)

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