Function and Biology

Recombinant Human Carboxylesterase 1 from whole Cabbage Loopers

Source organism: Homo sapiens
Biochemical function: carboxylesterase activity
Biological process: regulation of bile acid secretion
Cellular component: cytosol

EC 3.1.1.56: Methylumbelliferyl-acetate deacetylase

Reaction catalysed:
4-methylumbelliferyl acetate + H(2)O = 4-methylumbelliferone + acetate
Systematic name:
4-methylumbelliferyl-acetate acylhydrolase
Alternative Name(s):
  • Esterase D

EC 3.1.1.13: Sterol esterase

Reaction catalysed:
A steryl ester + H(2)O = a sterol + a fatty acid
Systematic name:
Steryl-ester acylhydrolase
Alternative Name(s):
  • Acylcholesterol lipase
  • Cholesterase
  • Cholesterol ester hydrolase
  • Cholesterol ester synthase
  • Cholesterol esterase
  • Cholesteryl ester hydrolase
  • Cholesteryl ester synthase
  • Cholesteryl esterase
  • Sterol ester hydrolase
  • Triterpenol esterase

EC 3.1.1.1: Carboxylesterase

Reaction catalysed:
A carboxylic ester + H(2)O = an alcohol + a carboxylate
Systematic name:
Carboxylic-ester hydrolase
Alternative Name(s):
  • Ali-esterase
  • Alpha-carboxylesterase
  • B-esterase
  • Butyrate esterase
  • Butyryl esterase
  • Carboxyesterase
  • Carboxyl ester hydrolase
  • Carboxylate esterase
  • Carboxylic acid esterase
  • Carboxylic esterase
  • Cocaine esterase
  • Esterase A
  • Esterase B
  • Esterase D
  • Methylbutyrase
  • Methylbutyrate esterase
  • Monobutyrase
  • Nonspecific carboxylesterase
  • Procaine esterase
  • Propionyl esterase
  • Serine esterase
  • Triacetin esterase
  • Vitamin A esterase

Sequence family

Pfam Protein family (Pfam)
PF00135
Domain description: Carboxylesterase family
Occurring in:
  1. Liver carboxylesterase 1
The deposited structure of PDB entry 4ab1 contains 1 copy of Pfam domain PF00135 (Carboxylesterase family) in Liver carboxylesterase 1. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR029058
Domain description: Alpha/Beta hydrolase fold
Occurring in:
  1. Liver carboxylesterase 1
IPR019826
Domain description: Carboxylesterase type B, active site
Occurring in:
  1. Liver carboxylesterase 1
IPR019819
Domain description: Carboxylesterase type B, conserved site
Occurring in:
  1. Liver carboxylesterase 1
IPR002018
Domain description: Carboxylesterase, type B
Occurring in:
  1. Liver carboxylesterase 1

Structure domain

CATH CATH domain
3.40.50.1820
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: alpha/beta hydrolase
Occurring in:
  1. Liver carboxylesterase 1
The deposited structure of PDB entry 4ab1 contains 1 copy of CATH domain 3.40.50.1820 (Rossmann fold) in Liver carboxylesterase 1. Showing 1 copy in chain A.