Function and Biology

Symmetrized cryo-EM reconstruction of E. coli DegQ 12-mer in complex with a binding peptide

Source organism: Escherichia coli K-12
Biochemical function: identical protein binding
Biological process: proteolysis involved in protein catabolic process
Cellular component: periplasmic space

EC 3.4.21.107: Peptidase Do

Reaction catalysed:
Acts on substrates that are at least partially unfolded. The cleavage site P1 residue is normally between a pair of hydrophobic residues, such as Val-|-Val
Systematic name:
-
Alternative Name(s):
  • DegP
  • DegP protease
  • Do protease
  • High temperature requirement protease A
  • HrtA heat shock protein
  • HtrA
  • Protease Do

Sequence families

Pfam Protein families (Pfam)
PF00595
Domain description: PDZ domain
Occurring in:
  1. Periplasmic pH-dependent serine endoprotease DegQ
The deposited structure of PDB entry 4a8c contains 24 copies of Pfam domain PF00595 (PDZ domain) in Periplasmic pH-dependent serine endoprotease DegQ. Showing 2 copies in chain A.

PF13365
Domain description: Trypsin-like peptidase domain
Occurring in:
  1. Periplasmic pH-dependent serine endoprotease DegQ
The deposited structure of PDB entry 4a8c contains 12 copies of Pfam domain PF13365 (Trypsin-like peptidase domain) in Periplasmic pH-dependent serine endoprotease DegQ. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001478
Domain description: PDZ domain
Occurring in:
  1. Periplasmic pH-dependent serine endoprotease DegQ
IPR001940
Domain description: Peptidase S1C
Occurring in:
  1. Periplasmic pH-dependent serine endoprotease DegQ
IPR036034
Domain description: PDZ superfamily
Occurring in:
  1. Periplasmic pH-dependent serine endoprotease DegQ
IPR008915
Domain description: Peptidase M50
Occurring in:
  1. Periplasmic pH-dependent serine endoprotease DegQ
IPR011782
Domain description: Peptidase S1C, Do
Occurring in:
  1. Periplasmic pH-dependent serine endoprotease DegQ
IPR009003
Domain description: Peptidase S1, PA clan
Occurring in:
  1. Periplasmic pH-dependent serine endoprotease DegQ