X-ray diffraction
2.4Å resolution

Factor Xa in complex with a potent 2-amino-ethane sulfonamide inhibitor

Source organism: Homo sapiens
Entry authors: Nazare M, Matter H, Will DW, Wagner M, Urmann M, Czech J, Schreuder H, Bauer A, Ritter K, Wehner V

Function and Biology Details

Reaction catalysed:
Selective cleavage of Arg-|-Thr and then Arg-|-Ile bonds in prothrombin to form thrombin.
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Factor X light chain Chain: A
Molecule details ›
Chain: A
Length: 96 amino acids
Theoretical weight: 10.53 KDa
Source organism: Homo sapiens
  • Canonical: P00742 (Residues: 84-179; Coverage: 21%)
Gene name: F10
Structure domains: Laminin
Activated factor Xa heavy chain Chain: B
Molecule details ›
Chain: B
Length: 254 amino acids
Theoretical weight: 28.55 KDa
Source organism: Homo sapiens
  • Canonical: P00742 (Residues: 235-488; Coverage: 56%)
Gene name: F10
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-3
Spacegroup: P212121
Unit cell:
a: 56.253Å b: 72.042Å c: 77.416Å
α: 90° β: 90° γ: 90°
R R work R free
0.198 0.198 0.253