X-ray diffraction
2.65Å resolution

Structure of mouse Acetylcholinesterase complex with Huprine derivative

Source organism: Mus musculus
Entry authors: Carletti E, Colletier JP, Nachon F, Weik M, Ronco C, Jean L, Renard PY

Function and Biology Details

Reaction catalysed:
Acetylcholine + H(2)O = choline + acetate
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Acetylcholinesterase Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 545 amino acids
Theoretical weight: 59.89 KDa
Source organism: Mus musculus
Expression system: Cricetulus griseus
  • Canonical: P21836 (Residues: 35-574; Coverage: 93%)
Gene name: Ache
Sequence domains: Carboxylesterase family
Structure domains: alpha/beta hydrolase

Ligands and Environments

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-4
Spacegroup: P212121
Unit cell:
a: 137.94Å b: 171.93Å c: 225.32Å
α: 90° β: 90° γ: 90°
R R work R free
0.157 0.155 0.206
Expression system: Cricetulus griseus