4a0z

X-ray diffraction
1.9Å resolution

Structure of the global transcription regulator FapR from Staphylococcus aureus in complex with malonyl-CoA

Released:
Source organism: Staphylococcus aureus
Entry authors: Albanesi D, Guerin ME, Buschiazzo A, de Mendoza D, Alzari PM

Function and Biology Details

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transcription factor FapR Chains: A, B
Molecule details ›
Chains: A, B
Length: 190 amino acids
Theoretical weight: 22.03 KDa
Source organism: Staphylococcus aureus
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q2FZ56 (Residues: 1-190; Coverage: 100%)
Gene names: SAOUHSC_01196, fapR
Sequence domains: Thioesterase superfamily
Structure domains:

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-4
Spacegroup: P21
Unit cell:
a: 53.38Å b: 68.5Å c: 61.16Å
α: 90° β: 111.31° γ: 90°
R-values:
R R work R free
0.2 0.198 0.236
Expression system: Escherichia coli BL21