PDBe 4zyp

X-ray diffraction
5.5Å resolution

Crystal Structure of Motavizumab and Quaternary-Specific RSV-Neutralizing Human Antibody AM14 in Complex with Prefusion RSV F Glycoprotein

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero 15-mer (preferred)
Entry contents:
5 distinct polypeptide molecules
Macromolecules (5 distinct):
Fibritin; Fusion glycoprotein F0 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 498 amino acids
Theoretical weight: 55.12 KDa
Source organisms: Expression system: Homo sapiens
UniProt:
  • Canonical: D9IEJ2 (Residues: 458-484; Coverage: 6%)
  • Canonical: P03420 (Residues: 26-513; Coverage: 84%)
  • nullnull
Gene names: F, T4Tp161, wac
Motavizumab antibody Fab heavy chain Chains: J, K, N
Molecule details ›
Chains: J, K, N
Length: 225 amino acids
Theoretical weight: 24.28 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
Motavizumab antibody light chain Chains: L, M, O
Molecule details ›
Chains: L, M, O
Length: 213 amino acids
Theoretical weight: 23.15 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
AM14 antibody Fab heavy chain Chains: D, F, H
Molecule details ›
Chains: D, F, H
Length: 227 amino acids
Theoretical weight: 24.37 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
AM14 antibody light chain Chains: E, G, I
Molecule details ›
Chains: E, G, I
Length: 215 amino acids
Theoretical weight: 23.62 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P21
Unit cell:
a: 114.38Å b: 210.29Å c: 118.2Å
α: 90° β: 100.46° γ: 90°
R-values:
R R work R free
0.214 0.21 0.277
Expression system: Homo sapiens