PDBe 4zqk

X-ray diffraction
2.45Å resolution

Structure of the complex of human programmed death-1 (PD-1) and its ligand PD-L1.

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Programmed cell death 1 ligand 1 Chain: A
Molecule details ›
Chain: A
Length: 115 amino acids
Theoretical weight: 13.13 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9NZQ7 (Residues: 18-132; Coverage: 42%)
Gene names: B7H1, CD274, PDCD1L1, PDCD1LG1, PDL1
Sequence domains: Immunoglobulin V-set domain
Structure domains: Immunoglobulins
Programmed cell death protein 1 Chain: B
Molecule details ›
Chain: B
Length: 118 amino acids
Theoretical weight: 13.23 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q15116 (Residues: 33-150; Coverage: 45%)
Gene names: PD1, PDCD1
Sequence domains: Immunoglobulin V-set domain
Structure domains: Immunoglobulins

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BESSY BEAMLINE 14.1
Spacegroup: P3121
Unit cell:
a: 70.862Å b: 70.862Å c: 114.367Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.209 0.207 0.253
Expression system: Escherichia coli BL21(DE3)