PDBe 4zii

X-ray diffraction
2.19Å resolution

Crystal Structure of core/latch dimer of BaxI66A in complex with BidBH3

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Apoptosis regulator BAX Chain: A
Molecule details ›
Chain: A
Length: 170 amino acids
Theoretical weight: 18.82 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q07812 (Residues: 1-170; Coverage: 89%)
  • Best match: Q07812-5 (Residues: 1-124)
Gene names: BAX, BCL2L4
Sequence domains: Apoptosis regulator proteins, Bcl-2 family
Structure domains: Blc2-like
BH3-interacting domain death agonist p11 Chain: C
Molecule details ›
Chain: C
Length: 34 amino acids
Theoretical weight: 3.69 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P55957 (Residues: 76-109; Coverage: 17%)
Gene name: BID

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX2
Spacegroup: P43212
Unit cell:
a: 103.801Å b: 103.801Å c: 38.007Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.18 0.175 0.223
Expression systems:
  • Escherichia coli
  • Not provided