PDBe 4zie

X-ray diffraction
1.8Å resolution

Crystal Structure of core/latch dimer of Bax in complex with BimBH3

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Bcl-2-like protein 11 Chain: C
Molecule details ›
Chain: C
Length: 26 amino acids
Theoretical weight: 3.27 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: O43521 (Residues: 141-166; Coverage: 13%)
Gene names: BCL2L11, BIM
Apoptosis regulator BAX Chain: A
Molecule details ›
Chain: A
Length: 168 amino acids
Theoretical weight: 18.51 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q07812 (Residues: 1-166; Coverage: 87%)
  • Best match: Q07812-5 (Residues: 1-124)
Gene names: BAX, BCL2L4
Sequence domains: Apoptosis regulator proteins, Bcl-2 family
Structure domains: Blc2-like

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX2
Spacegroup: P43212
Unit cell:
a: 95.44Å b: 95.44Å c: 36.353Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.186 0.182 0.229
Expression systems:
  • Not provided
  • Escherichia coli