PDBe 4xoj

X-ray diffraction
0.91Å resolution

Structure of bovine trypsin in complex with analogues of sunflower inhibitor 1 (SFTI-1)


Function and Biology Details

Reaction catalysed:
Preferential cleavage: Arg-|-, Lys-|-.
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Cationic trypsin Chain: A
Molecule details ›
Chain: A
Length: 246 amino acids
Theoretical weight: 25.81 KDa
Source organism: Bos taurus
  • Canonical: P00760 (Residues: 1-246; Coverage: 100%)
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases
Trypsin inhibitor 1 Chain: B
Molecule details ›
Chain: B
Length: 13 amino acids
Theoretical weight: 1.42 KDa
Source organism: Helianthus annuus
Expression system: Not provided
  • Canonical: Q4GWU5 (Residues: 40-52; Coverage: 42%)
Gene name: sfti1

Ligands and Environments

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PETRA III, EMBL c/o DESY BEAMLINE P13 (MX1)
Spacegroup: P212121
Unit cell:
a: 62.39Å b: 63.05Å c: 69.17Å
α: 90° β: 90° γ: 90°
R R work R free
0.104 0.103 0.114
Expression system: Not provided