PDBe 4xbu

X-ray diffraction
2.06Å resolution

In vitro Crystal Structure of PAK4 in complex with Inka peptide

Released:

Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
PAK4-inhibitor INKA1 Chain: B
Molecule details ›
Chain: B
Length: 24 amino acids
Theoretical weight: 2.66 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q96EL1 (Residues: 167-190; Coverage: 8%)
Gene names: C3orf54, FAM212A, INKA1
Serine/threonine-protein kinase PAK 4 Chain: A
Molecule details ›
Chain: A
Length: 326 amino acids
Theoretical weight: 37.05 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O96013 (Residues: 286-591; Coverage: 52%)
Gene names: KIAA1142, PAK4
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

No bound ligands

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I24
Spacegroup: P41212
Unit cell:
a: 65.62Å b: 65.62Å c: 184.15Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.201 0.199 0.243
Expression systems:
  • Not provided
  • Escherichia coli