PDBe 4xbr

X-ray diffraction
2.94Å resolution

In cellulo Crystal Structure of PAK4 in complex with Inka

Released:

Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
PAK4-inhibitor INKA1; Serine/threonine-protein kinase PAK 4 Chain: A
Molecule details ›
Chain: A
Length: 366 amino acids
Theoretical weight: 41.25 KDa
Source organism: Homo sapiens
Expression system: Chlorocebus aethiops
UniProt:
  • Canonical: Q96EL1 (Residues: 166-203; Coverage: 13%)
  • Canonical: O96013 (Residues: 278-591; Coverage: 53%)
  • nullnull
Gene names: C3orf54, FAM212A, INKA1, KIAA1142, PAK4
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

2 bound ligands:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I24
Spacegroup: P63
Unit cell:
a: 144.04Å b: 144.04Å c: 62.51Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.191 0.189 0.23
Expression system: Chlorocebus aethiops