PDBe 4x97

X-ray diffraction
2.65Å resolution

Crystal structure of Lysosomal Phospholipase A2 in complex with methyl arachidonyl fluorophosphonate (MAFP)


Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Group XV phospholipase A2 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 380 amino acids
Theoretical weight: 43.12 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
  • Canonical: Q8NCC3 (Residues: 34-412; Coverage: 100%)
Gene names: LYPLA3, PLA2G15, UNQ341/PRO540
Sequence domains: Lecithin:cholesterol acyltransferase
Structure domains: Rossmann fold

Ligands and Environments

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-D
Spacegroup: P1
Unit cell:
a: 69.147Å b: 85.495Å c: 88.852Å
α: 88.85° β: 70.87° γ: 79.74°
R R work R free
0.181 0.179 0.219
Expression system: Homo sapiens