PDBe 4wuw

X-ray diffraction
2.4Å resolution

Crystal Structure of Surfactant Protein-A DED Mutant (E171D/P175E/K203D) Complexed with Inositol

Released:
Source organism: Rattus norvegicus
Entry authors: Rynkiewicz MJ, Wu H, Cafarella TR, Nikolaidis NM, Head JF, Seaton BA, McCormack FX

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Pulmonary surfactant-associated protein A Chain: A
Molecule details ›
Chain: A
Length: 148 amino acids
Theoretical weight: 16.71 KDa
Source organism: Rattus norvegicus
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P08427 (Residues: 101-248; Coverage: 65%)
Gene names: Sftp-1, Sftp1, Sftpa, Sftpa1
Sequence domains: Lectin C-type domain
Structure domains: Mannose-Binding Protein A, subunit A

Ligands and Environments

2 bound ligands:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU300
Spacegroup: P63
Unit cell:
a: 97.699Å b: 97.699Å c: 45.027Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.177 0.174 0.204
Expression system: Trichoplusia ni