4wi5

X-ray diffraction
2.8Å resolution

Structural mapping of the human IgG1 binding site for FcRn: hu3S193 Fc mutation H310A

Released:
Source organism: Homo sapiens
Entry authors: Farrugia W, Burvenich IJG, Scott AM, Ramsland PA

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Immunoglobulin heavy constant gamma 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 208 amino acids
Theoretical weight: 23.57 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P01857 (Residues: 120-327; Coverage: 63%)
Gene name: IGHG1
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins

Ligands and Environments


No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX2
Spacegroup: P212121
Unit cell:
a: 49.004Å b: 77.483Å c: 136.683Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.234 0.227 0.301
Expression system: Homo sapiens