PDBe 4wci

X-ray diffraction
1.65Å resolution

Crystal structure of the 1st SH3 domain from human CD2AP (CMS) in complex with a proline-rich peptide (aa 378-393) from human RIN3

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
CD2-associated protein Chains: A, C, E
Molecule details ›
Chains: A, C, E
Length: 65 amino acids
Theoretical weight: 7.59 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9Y5K6 (Residues: 1-60; Coverage: 9%)
Gene name: CD2AP
Sequence domains: Variant SH3 domain
Structure domains: SH3 Domains
Ras and Rab interactor 3 Chains: B, D, F
Molecule details ›
Chains: B, D, F
Length: 16 amino acids
Theoretical weight: 1.83 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q8TB24 (Residues: 378-393; Coverage: 2%)
Gene name: RIN3

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04
Spacegroup: C2
Unit cell:
a: 95.526Å b: 55.362Å c: 64.557Å
α: 90° β: 131.72° γ: 90°
R-values:
R R work R free
0.194 0.192 0.219
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided