4uxh

X-ray diffraction
2.4Å resolution

Leishmania major Thymidine Kinase in complex with AP5dT

Released:

Function and Biology Details

Reaction catalysed:
ATP + thymidine = ADP + thymidine 5'-phosphate
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Thymidine kinase Chains: A, B
Molecule details ›
Chains: A, B
Length: 184 amino acids
Theoretical weight: 21.03 KDa
Source organism: Leishmania major
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q4QC75 (Residues: 2-183; Coverage: 64%)
Gene name: LMJF_21_1210
Sequence domains: Thymidine kinase
Structure domains:

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I24
Spacegroup: P6522
Unit cell:
a: 64.149Å b: 64.149Å c: 324.6Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.198 0.195 0.257
Expression system: Spodoptera frugiperda