X-ray diffraction
1.13Å resolution

Crystal Structure of a GDP-bound G13D Oncogenic Mutant of Human GTPase KRas


Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
GTPase KRas, N-terminally processed Chains: A, B
Molecule details ›
Chains: A, B
Length: 169 amino acids
Theoretical weight: 19.26 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
  • Canonical: P01116 (Residues: 1-167; Coverage: 88%)
  • Best match: P01116-2 (Residues: 1-168)
Gene names: KRAS, KRAS2, RASK2
Sequence domains: Ras family
Structure domains: P-loop containing nucleotide triphosphate hydrolases

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: C2
Unit cell:
a: 66.157Å b: 41.283Å c: 114.464Å
α: 90° β: 105.03° γ: 90°
R R work R free
0.141 0.14 0.168
Expression system: Escherichia coli BL21