4tmk

X-ray diffraction
1.98Å resolution

COMPLEX OF E. COLI THYMIDYLATE KINASE WITH THE BISUBSTRATE INHIBITOR TP5A

Released:

Function and Biology Details

Reaction catalysed:
ATP + dTMP = ADP + dTDP
Biochemical function:
Cellular component:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo hexamer
homo dimer
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Thymidylate kinase Chain: A
Molecule details ›
Chain: A
Length: 213 amino acids
Theoretical weight: 23.83 KDa
Source organism: Escherichia coli
Expression system: Escherichia coli
UniProt:
  • Canonical: P0A720 (Residues: 1-213; Coverage: 100%)
Gene names: JW1084, b1098, tmk, ycfG
Sequence domains: Thymidylate kinase
Structure domains: P-loop containing nucleotide triphosphate hydrolases

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: MPG/DESY, HAMBURG BEAMLINE BW6
Spacegroup: R32
Unit cell:
a: 151.7Å b: 151.7Å c: 74.48Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.204 0.204 0.253
Expression system: Escherichia coli