PDBe 4tkn

X-ray diffraction
3Å resolution

Structure of the SNX17 FERM domain bound to the second NPxF motif of KRIT1

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Sorting nexin-17 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 286 amino acids
Theoretical weight: 32.47 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q15036 (Residues: 108-391; Coverage: 60%)
Gene names: KIAA0064, SNX17
Sequence domains: Sorting Nexin 17 FERM C-terminal domain
Structure domains:
Krev interaction trapped protein 1 Chains: D, E, F
Molecule details ›
Chains: D, E, F
Length: 19 amino acids
Theoretical weight: 1.92 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O00522 (Residues: 225-237; Coverage: 2%)
Gene names: CCM1, KRIT1

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-E
Spacegroup: C2
Unit cell:
a: 117.924Å b: 191.202Å c: 46.593Å
α: 90° β: 110.25° γ: 90°
R-values:
R R work R free
0.223 0.218 0.268
Expression system: Escherichia coli