X-ray diffraction
1.95Å resolution

Crystal Structure of the VAV2 SH2 domain in complex with TXNIP phosphorylated peptide

Source organism: Homo sapiens
Entry authors: Liu Y, Tempel W, Bountra C, Arrowsmith CH, Edwards AM, Min J, Structural Genomics Consortium (SGC)

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Guanine nucleotide exchange factor VAV2 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 117 amino acids
Theoretical weight: 13.76 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
  • Canonical: P52735 (Residues: 667-782; Coverage: 13%)
Gene name: VAV2
Sequence domains: SH2 domain
Structure domains: SH2 domain
Thioredoxin-interacting protein Chains: D, E, F
Molecule details ›
Chains: D, E, F
Length: 14 amino acids
Theoretical weight: 1.44 KDa
Source organism: Homo sapiens
Expression system: Not provided
  • Canonical: Q9H3M7 (Residues: 327-338; Coverage: 3%)
Gene names: TXNIP, VDUP1

Ligands and Environments

1 bound ligand:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
Spacegroup: P6122
Unit cell:
a: 99.764Å b: 99.764Å c: 160.946Å
α: 90° β: 90° γ: 120°
R R work R free
0.187 0.186 0.219
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided