PDBe 4rlp

X-ray diffraction
2.79Å resolution

Human p70s6k1 with ruthenium-based inhibitor FL772

Released:

Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ribosomal protein S6 kinase beta-1 Chain: A
Molecule details ›
Chain: A
Length: 288 amino acids
Theoretical weight: 32.69 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P23443 (Residues: 85-372; Coverage: 55%)
Gene names: RPS6KB1, STK14A
Sequence domains: Protein kinase domain

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X29A
Spacegroup: C2221
Unit cell:
a: 62.13Å b: 126.371Å c: 110.571Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.208 0.206 0.23
Expression system: Spodoptera frugiperda