PDBe 4rh9

X-ray diffraction
1.6Å resolution

Crystal structure of PTPN3 (PTPH1) H812F, M883G mutant in complex with Eps15 pTyr849 peptide


Function and Biology Details

Reaction catalysed:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Tyrosine-protein phosphatase non-receptor type 3 Chain: A
Molecule details ›
Chain: A
Length: 306 amino acids
Theoretical weight: 34.82 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: P26045 (Residues: 628-909; Coverage: 31%)
Gene names: PTPH1, PTPN3
Sequence domains: Protein-tyrosine phosphatase
Structure domains: Protein tyrosine phosphatase superfamily
Epidermal growth factor receptor substrate 15 Chain: B
Molecule details ›
Chain: B
Length: 9 amino acids
Theoretical weight: 1.12 KDa
Source organism: Homo sapiens
Expression system: Not provided
  • Canonical: P42566 (Residues: 846-854; Coverage: 1%)
Gene names: AF1P, EPS15

Ligands and Environments

No bound ligands

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: NSRRC BEAMLINE BL15A1
Spacegroup: P212121
Unit cell:
a: 58.084Å b: 67.63Å c: 69.754Å
α: 90° β: 90° γ: 90°
R R work R free
0.196 0.194 0.226
Expression systems:
  • Escherichia coli
  • Not provided