4r8v

X-ray diffraction
2.2Å resolution

Crystal structure of the hydrolase domain of 10-formyltetrahydrofolate dehydrogenase (wild-type) complex with formate

Released:

Function and Biology Details

Reaction catalysed:
10-formyltetrahydrofolate + NADP(+) + H(2)O = tetrahydrofolate + CO(2) + NADPH
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
10-formyltetrahydrofolate dehydrogenase Chain: A
Molecule details ›
Chain: A
Length: 318 amino acids
Theoretical weight: 35.46 KDa
Source organism: Danio rerio
Expression system: Escherichia coli
UniProt:
  • Canonical: E3NZ06 (Residues: 1-311; Coverage: 34%)
Gene name: aldh1l1
Sequence domains:
Structure domains:

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSRRC BEAMLINE BL13C1
Spacegroup: P21212
Unit cell:
a: 103.98Å b: 51.977Å c: 59.936Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.195 0.193 0.237
Expression system: Escherichia coli