4r11

X-ray diffraction
2.79Å resolution

A conserved phosphorylation switch controls the interaction between cadherin and beta-catenin in vitro and in vivo

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Beta-catenin-like protein hmp-2 Chains: A, C, E
Molecule details ›
Chains: A, C, E
Length: 572 amino acids
Theoretical weight: 62.33 KDa
Source organism: Caenorhabditis elegans
Expression system: Escherichia coli
UniProt:
  • Canonical: O44326 (Residues: 53-621; Coverage: 84%)
Gene names: K05C4.6, hmp-2
Sequence domains: Armadillo/beta-catenin-like repeat
Structure domains: Leucine-rich Repeat Variant
Cadherin-related hmr-1 Chains: B, D, F
Molecule details ›
Chains: B, D, F
Length: 84 amino acids
Theoretical weight: 9.48 KDa
Source organism: Caenorhabditis elegans
Expression system: Escherichia coli
UniProt:
  • Canonical: Q967F4 (Residues: 2841-2920; Coverage: 3%)
Gene names: W02B9.1, hmr-1

Ligands and Environments

1 bound ligand:

2 modified residues:

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL11-1
Spacegroup: P21
Unit cell:
a: 85.057Å b: 157.716Å c: 84.824Å
α: 90° β: 94.2° γ: 90°
R-values:
R R work R free
0.203 0.199 0.249
Expression system: Escherichia coli