PDBe 4qim

X-ray diffraction
2.61Å resolution

Structure of the human smoothened receptor in complex with ANTA XV

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Smoothened homolog; Soluble cytochrome b562 Chain: A
Molecule details ›
Chain: A
Length: 468 amino acids
Theoretical weight: 52.4 KDa
Source organisms: Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P0ABE7 (Residues: 23-128; Coverage: 100%)
  • Canonical: Q99835 (Residues: 190-433, 441-555; Coverage: 47%)
  • nullnull
Gene names: SMO, SMOH, cybC
Sequence domains: Cytochrome b562

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-D
Spacegroup: P212121
Unit cell:
a: 42.83Å b: 79.84Å c: 170.07Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.226 0.223 0.263
Expression system: Spodoptera frugiperda