4qei

X-ray diffraction
2.88Å resolution

Two distinct conformational states of GlyRS captured in crystal lattice

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Entry contents:
1 distinct polypeptide molecule
1 distinct RNA molecule
Macromolecules (2 distinct):
Glycine--tRNA ligase Chain: A
Molecule details ›
Chain: A
Length: 630 amino acids
Theoretical weight: 71.76 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P41250 (Residues: 118-739; Coverage: 84%)
Gene names: GARS, GARS1
Sequence domains:
tRNA-Gly-CCC-2-2 Chain: C
Molecule details ›
Chain: C
Length: 69 nucleotides
Theoretical weight: 22.33 KDa
Source organism: Homo sapiens
Expression system: Not provided
Sequence domains: tRNA

Ligands and Environments

1 bound ligand:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: P21212
Unit cell:
a: 134.605Å b: 88.446Å c: 81.206Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.216 0.214 0.265
Expression systems:
  • Escherichia coli
  • Not provided