X-ray diffraction
3.1Å resolution

Crystal structure of P2Y12 receptor in complex with 2MeSATP


Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
P2Y purinoceptor 12; Soluble cytochrome b562 Chain: A
Molecule details ›
Chain: A
Length: 466 amino acids
Theoretical weight: 53.25 KDa
Source organisms: Expression system: Spodoptera frugiperda
  • Canonical: P0ABE7 (Residues: 23-128; Coverage: 100%)
  • Canonical: Q9H244 (Residues: 2-223, 224-342; Coverage: 100%)
Gene names: HORK3, P2RY12, cybC
Sequence domains:

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL41XU
Spacegroup: C2
Unit cell:
a: 75.65Å b: 65.11Å c: 100.74Å
α: 90° β: 95.5° γ: 90°
R R work R free
0.224 0.222 0.265
Expression system: Spodoptera frugiperda