X-ray diffraction
2Å resolution

Crystal Structure of the Stress-Inducible Human Heat Shock Protein HSP70 Substrate-Binding Domain in Complex with Peptide Substrate


Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assemblies composition:
hetero dimer (preferred)
hetero octamer
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Heat shock 70 kDa protein 1A Chains: A, B
Molecule details ›
Chains: A, B
Length: 235 amino acids
Theoretical weight: 26.28 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: P0DMV8 (Residues: 386-613; Coverage: 36%)
Gene names: HSP72, HSPA1, HSPA1A, HSX70
Structure domains:
HSP70 substrate peptide Chains: C, D
Molecule details ›
Chains: C, D
Length: 7 amino acids
Theoretical weight: 787 Da
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X29A
Spacegroup: C2
Unit cell:
a: 100.293Å b: 85.282Å c: 72.199Å
α: 90° β: 126.97° γ: 90°
R R work R free
0.177 0.175 0.222
Expression systems:
  • Escherichia coli
  • Not provided