X-ray diffraction
1.35Å resolution

tubulin acetyltransferase complex with bisubstrate analog


Function and Biology Details

Reaction catalysed:
Acetyl-CoA + [alpha-tubulin]-L-lysine = CoA + [alpha-tubulin]-N(6)-acetyl-L-lysine
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Alpha-tubulin N-acetyltransferase 1 Chain: A
Molecule details ›
Chain: A
Length: 198 amino acids
Theoretical weight: 22.74 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: Q5SQI0 (Residues: 1-197; Coverage: 47%)
  • Best match: Q5SQI0-6 (Residues: 1-196)
Gene names: ATAT1, C6orf134, MEC17, Nbla00487
Sequence domains: GNAT acetyltransferase, Mec-17
Structure domains: Aminopeptidase
Molecule details ›
Chain: B
Length: 6 amino acids
Theoretical weight: 530 Da
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

Cofactor: Ligand COA 1 x COA
No bound ligands
1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.1
Spacegroup: P21
Unit cell:
a: 37.124Å b: 52.483Å c: 50.285Å
α: 90° β: 106.83° γ: 90°
R R work R free
0.133 0.131 0.168
Expression systems:
  • Escherichia coli
  • Not provided